National study during the peak of the second wave between April and June 2021, it is likely to be the largest and first study throughout the country for post-vaccination breakthrough infections from India with 677 clinical samples
Less hopsititalization (9.8%) and death (0.4%) reported in people who experienced a breakthrough of Coronavirus (Covid-19) after two doses of vaccines, highlighting the fact that vaccination did reduce hospital admission and mortality, according to pre- Print study.
National studies conducted by the Indian Medical Research Council (ICMR) during the peak of the second wave between April and June 2021, is likely to be the largest study throughout the largest country of post-vaccination breakthrough infections from India with 677 clinical samples.
The vaccine used for this study was Bharat Biotech’s Covaxin and Serum Institute of Oxford-Astrazeneca India vaccine produced locally as a covishield.
“” During March to June 2021, India has experienced a second wave of Covid-19 which turned off with the increasing number of post-vaccinated breakthrough infections reported throughout the country. To understand the possibility of this breakthrough reason, we collect 677 clinical samples (swab throat / nose swabs) of individuals who have received two doses (n = 592) and one dose (n = 85) vaccines (covishield and covaxin) and tested positive covid-19 , Of the 17 states / state union areas, “said study papers.
These cases were interviewed by telephone and clinical data were analyzed. Of the 677 cases included in this study, 593 were clinical samples from breakthroughs and 84 experienced infections after one dose.
A total of 482 cases (71%) are symptomatic with one or more symptoms, while 29% have SARS-COV-2 infection without symptoms. Fever (69%) is the most consistent presentation followed by body pain including headaches and nausea (56%), cough (45%), sore throat (37%), odor loss and taste (22%), diarrhea (6% )), Shortness of breath (6%) and 1% have ocular irritation and redness.
“This study showed that the majority of clinical cases in the breakthrough were infected with Delta variants and only 9.8% of cases needed to be inpatient while death was observed only in case of 0.4%. This clearly shows that vaccination does provide a reduction in the admission and mortality of the hospital,” Find research.
The purpose of this study was to eliminate concerns about vaccination with the increasing protection questions offered by the vaccine after the emergence of a variant of concern and reducing the real world effectiveness of the candidate vaccine against this variant.
The Indian Medical Research Council – Department of Health Research (ICMR-DHR) utilizes a Virus Research Network and Diagnostic Laboratory (VRDL) to track breakthrough infections.
Breakthrough casts are defined as detection of RNA or SARS-COV-2 antigens in respiratory samples collected from someone 14 days after receiving all recommended Covid-19 vaccine doses.
“Observed that the southern, west, east and northwest regions in India were dominantly reported a breakthrough infection of Delta, especially and then Kappa variants from SARS-COV-2. The northern region and the center reported such infection because of the alpha, delta and kappa variants; However, the case because the alpha variant dominated in the northern region. The overall majority (86.09%) of breakthrough infections was caused by the Delta variant (B.1.617.2) from SARS-COV-2 in various Indian regions except for the northern region where the variant Alfa dominated, “the researchers said in this study.